AAKG and arginine, what’s the difference? Arginine Alpha-Ketoglutarate (AAKG) is 2 L-Arginine molecules joined to 1 Alpha-Ketoglutarate. This increases its bioavailability. Regular L-arginine can be dosed up to 20g a day whilst AAKG is effective from 1.5 to 3.5g per day. Pure arginine is consumed quickly in the body, with a significant loss in the digestion process. AAKG steadily releases arginine in the bloodstream while also decreasing the loss in the digestion process, with better flow of arginine in the bloodstream.